The relationship between parkinson syndrome and vascular siderosis: An electron microprobe study
Identifieur interne : 000329 ( France/Analysis ); précédent : 000328The relationship between parkinson syndrome and vascular siderosis: An electron microprobe study
Auteurs : Duckett [États-Unis, France] ; Pierre Galle [États-Unis, France] ; Richard Kradin [États-Unis, France]Source :
- Annals of Neurology [ 0364-5134 ] ; 1977-09.
Abstract
Vascular siderosis (VS) refers to the presence of mineralized small and medium‐sized arteries in the globus pallidus, usually regarded as reflecting an aging process. The electron probe analysis of deposits in vascular siderosis in 10 patients dying of parkinsonism and in 8 other patients without parkinsonism is reported here. The microprobes identified a total of 11 elements in the VS in these 18 patients. Five elements—lead, aluminum, sulfur, manganese, and barium—were present only in VS associated with parkinsonism. Statistically, the association of lead was highly significant while that of aluminium and sulfur was only suggestive. Lead was present in 7 of the 10 patients with parkinsonism and aluminium and sufur in 4. The significance of the presence of sulfur is difficult to assess since its compounds are normally present in large quantities in the brain. These findings raise the question whether lead and aluminum may be associated in some way with the pathogenesis of certain forms of Parkinson disease.
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DOI: 10.1002/ana.410020308
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ISTEX:C2EC4E5658F0EB61AD172B7EC17F03307F43F31ALe document en format XML
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The electron probe analysis of deposits in vascular siderosis in 10 patients dying of parkinsonism and in 8 other patients without parkinsonism is reported here. The microprobes identified a total of 11 elements in the VS in these 18 patients. Five elements—lead, aluminum, sulfur, manganese, and barium—were present only in VS associated with parkinsonism. Statistically, the association of lead was highly significant while that of aluminium and sulfur was only suggestive. Lead was present in 7 of the 10 patients with parkinsonism and aluminium and sufur in 4. The significance of the presence of sulfur is difficult to assess since its compounds are normally present in large quantities in the brain. These findings raise the question whether lead and aluminum may be associated in some way with the pathogenesis of certain forms of Parkinson disease.</div></front></TEI><affiliations><list><country><li>France</li><li>États-Unis</li></country><region><li>Pennsylvanie</li><li>Île-de-France</li></region><settlement><li>Créteil</li></settlement></list><tree><country name="États-Unis"><region name="Pennsylvanie"><name sortKey="Duckett" sort="Duckett" uniqKey="Duckett" last="Duckett">Duckett</name></region><name sortKey="Galle, Pierre" sort="Galle, Pierre" uniqKey="Galle P" first="Pierre" last="Galle">Pierre Galle</name><name sortKey="Kradin, Richard" sort="Kradin, Richard" uniqKey="Kradin R" first="Richard" last="Kradin">Richard Kradin</name></country><country name="France"><region name="Île-de-France"><name sortKey="Duckett" sort="Duckett" uniqKey="Duckett" last="Duckett">Duckett</name></region><name sortKey="Galle, Pierre" sort="Galle, Pierre" uniqKey="Galle P" first="Pierre" last="Galle">Pierre Galle</name><name sortKey="Kradin, Richard" sort="Kradin, Richard" uniqKey="Kradin R" first="Richard" last="Kradin">Richard Kradin</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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